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Fimepinostat

Fimepinostat

Item no.	HY-13522-25mg
Manufacturer	MedChem Express
CASRN	1339928-25-4
Amount	25 mg
Quantity options	100 mg 10mM/1mL 10 mg 25 mg 2 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Lineage Markers Neural Transcription Factors Aging & Neurological Disorders Neural Signaling Neural Epigenetics Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Breast Cancer Heart & Blood Cancer
Type	Inhibitors
Specific against	other
Purity	99.95
Citations	[1]Qian C, et al. Cancer network disruption by a single molecule inhibitor targeting both histone deacetylase activity and phosphatidylinositol 3-kinase signaling. Clin Cancer Res. 2012 Aug 1;18(15):4104-13.
Smiles	O=C(C1=CN=C(N(CC2=CC3=NC(C4=CC=C(OC)N=C4)=NC(N5CCOCC5)=C3S2)C)N=C1)NO
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	CUDC-907
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Apoptosis; HDAC; PI3K
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	508.55
Product Description	Fimepinostat (CUDC-907) potently inhibits class I PI3Ks as well as classes I and II HDAC enzymes with an IC50 of 19/54/39 nM and 1.7/5.0/1.8/2.8 nM for PI3Kα/PI3Kβ/PI3Kδ and HDAC1/HDAC2/HDAC3/HDAC10 , respectively.
Manufacturer - Research Area	Cancer
Solubility	DMF: 5 mg/mL (ultrasonic)\|DMSO: 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR
Isoform	HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC4; HDAC5; HDAC6; HDAC7; HDAC8; HDAC9; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
Clinical information	Phase 2

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HY-13522-25mg-safety-datasheet.pdf