« Back
Home /
Gamcemetinib

Gamcemetinib

Item no.	HY-139504-10mM
Manufacturer	MedChem Express
CASRN	1887069-10-4
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	99.06
Citations	[1]WO2020236636
Smiles	O=C1C2=C(NC[C@H](N1)C)C3=C(S2)C=CC4=NC(OC5=NC(Cl)=NC=C5COCC)=CC=C34
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	CC-99677
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	MAPKAPK2 (MK2)
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	469.94
Product Description	Gamcemetinib (CC-99677) is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2) pathway in both biochemical (IC50=156.3 nM) and cell based assays (EC50=89 nM). Gamcemetinib is extracted from patent WO2020236636, compound 1[1].
Manufacturer - Research Area	Inflammation/Immunology
Solubility	DMSO: 37.5 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	MAPK/ERK Pathway
Clinical information	Phase 2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

HY-139504-10mM-safety-datasheet.pdf