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AMG 837 (calcium hydrate)

AMG 837 (calcium hydrate)

Item no.	HY-13967B-25mg
Manufacturer	MedChem Express
CASRN	1259389-38-2
Amount	25 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Regulation of Appetite Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.00
Citations	[1]Daniel CHL, et, al. AMG 837: a novel GPR40/FFA1 agonist that enhances insulin secretion and lowers glucose levels in rodents. PLoS One. 2011; 6(11): e27270.\|[2]Houze JB, et, al. AMG 837: a potent, orally bioavailable GPR40 agonist. Bioorg Med Chem Lett. 2012 Jan 15; 22(2): 1267-70.\|[3]Daniel CHL, et, al. Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor. Mol Pharmacol. 2012 Nov;82(5):843-59. Biochem Biophys Res Commun. 2025 Mar 12:757:151624.\|Biomed Pharmacother. 2023 May.
Smiles	OC(C[C@H](C#CC)C(C=C1)=CC=C1OCC2=CC=CC(C3=CC=C(C=C3)C(F)(F)F)=C2)=O.[Ca].O.[1/2]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Metabolism-sugar/lipid metabolism
Manufacturer - Targets	Free Fatty Acid Receptor
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	455.45
Product Description	AMG 837 calcium hydrate is a potent, orally bioavailable and partial agonist of GPR40/FFA1. AMG 837 calcium hydrate inhibits specific [3H]AMG 837 binding at the human FFA1 receptor with a pIC50 of 8.13. AMG 837 calcium hydrate could enhance insulin secretion and lower glucose levels in rodents[1][2][3]. AMG 837 (calcium hydrate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Manufacturer - Research Area	Metabolic Disease
Solubility	DMSO: ≥ 42 mg/mL
Manufacturer - Pathway	GPCR/G Protein
Clinical information	No Development Reported

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HY-13967B-25mg-safety-datasheet.pdf