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Homoharringtonine

Homoharringtonine

Item no.	HY-14944-25mg
Manufacturer	MedChem Express
CASRN	26833-87-4
Amount	25 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Heart & Blood Cancer
Type	Inhibitors
Specific against	other
Purity	99.96
Citations	[1]Cao W, et al. Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells. Sci Rep. 2015 Jul 13;5:8477\|[2]Yakhni M, et al. Homoharringtonine, an approved anti-leukemia drug, suppresses triple negative breast cancer growth through a rapid reduction of anti-apoptotic protein abundance. Am J Cancer Res. 2019 May 1;9(5):1043-1060.
Smiles	[H][C@@]12[C@](CCC3)(C=C(OC)[C@]2(OC([C@](CCCC(O)(C)C)(O)CC(OC)=O)=O)[H])N3CCC4=CC5=C(OCO5)C=C14
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Omacetaxine mepesuccinate,HHT
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	STAT
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Molecular Weight	545.62
Product Description	Homoharringtonine (Omacetaxine mepesuccinate; HHT) is a cytotoxic alkaloid with antitumor properties which acts by inhibiting translation elongation.
Manufacturer - Research Area	Cancer
Solubility	DMSO: ≥ 50 mg/mL\|H2O: 1.4 mg/mL (ultrasonic)
Manufacturer - Pathway	JAK/STAT Signaling; Stem Cell/Wnt
Isoform	STAT3
Clinical information	Launched

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HY-14944-25mg-safety-datasheet.pdf