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Sildenafil

Sildenafil

Item no.	HY-15025-1g
Manufacturer	MedChem Express
CASRN	139755-83-2
Amount	1 g
Quantity options	100 mg 10 g 10 mM/1 mL 10 mg 1 g 200 mg 500 mg 50 mg 5 g
Category	Oncology Neuroscience Neural Signaling Cardiovascular Research Thrombosis & Hemostasis Hypertension Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer
Type	Inhibitors
Specific against	other
Purity	99.97
Citations	[1]Wang Z, et al. The Selectivity and Potency of the New PDE5 Inhibitor TPN729MA. J Sex Med. 2013 Nov;10(11):2790-7.\|[2]Li BB, et al. Sildenafil potentiates the proliferative effect of porcine pulmonary artery smooth muscle cells induced by serotonin in vitro. Chin Med J (Engl). 2011 Sep;124(17):2733-40.\|[3]Moretti R, et al. Sildenafil, a cyclic GMP phosphodiesterase inhibitor, induces microglial modulation after focal ischemia in the neonatal mouse brain. J Neuroinflammation. 2016 Apr 28;13(1):95.\|[4]Korkmaz MF, et al. The Effect of Sildenafil on Recuperation from Sciatic Nerve Injury in Rats. Balkan Med J. 2016 Mar;33(2):204-11. ACS Omega. 2020 Nov 15;5(46):29935-29942.\|Biochem Biophys Res Commun. 2021 Feb 12;547:9-14.\|Biochim Biophys Acta Mol Basis Dis. 2024 Jan 5:167018.\|Bioeng Transl Med. 2023 Jul 2.\|Biomed Chromatogr. 2024 Jun 5:e5925.\|Br J Pharmacol. 2024 Sep 10.\|Int J Mol Sci. 2022 Jun 20;23(12):6860.\|Physiol Rep. 2023 Jan;11(1):e15549.\|Phytother Res. 2025 Jan 30.\|Sci Rep. 2020 Oct 2;10(1):16383.
Smiles	O=C1C(N(C)N=C2CCC)=C2N=C(C3=CC(S(=O)(N4CCN(C)CC4)=O)=CC=C3OCC)N1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	UK-92480
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Apoptosis; Autophagy; Bacterial; Phosphodiesterase (PDE)
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	474.58
Product Description	Sildenafil (UK-92480) is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM.
Manufacturer - Research Area	Cardiovascular Disease; Cancer
Solubility	DMSO: 100 mg/mL (ultrasonic)\|H2O: < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Anti-infection; Apoptosis; Autophagy; Metabolic Enzyme/Protease
Isoform	PDE5
Clinical information	Launched

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HY-15025-1g-safety-datasheet.pdf