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COX-2-IN-32

COX-2-IN-32

Item no.	HY-153762-50mg
Manufacturer	MedChem Express
CASRN	2725863-08-9
Amount	50 mg
Quantity options	10 mg 1 ea 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Citations	[1]Emam SH, et al. Design and synthesis of methoxyphenyl- and coumarin-based chalcone derivatives as anti-inflammatory agents by inhibition of NO production and down-regulation of NF-κB in LPS-induced RAW264.7 macrophage cells. Bioorg Chem. 2021 Feb;107:104630.
Smiles	COC(C=C1)=CC=C1OC(C=C2)=CC=C2/C=C/C(C3=CC(OC)=C(C(OC)=C3)OC)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	COX; NF-κB; NO Synthase
Shipping Temperature	Room temperature
Molecular Weight	420.45
Product Description	COX-2-IN-32 (Compound 2f) is an iNOS and COX-2 inhibitor. COX-2-IN-32 decreases the expression of NF-κB . COX-2-IN-32 has anti-inflammatory activity by inhibits NO production in LPS-induced RAW264.7 macrophages (IC 50 : 11.2 μM) [1] .
Manufacturer - Research Area	Inflammation/Immunology
Solubility	10 mM in DMSO
Manufacturer - Pathway	Immunology/Inflammation; NF-κB
Isoform	COX-2
Clinical information	No Development Reported

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