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N2-iBu-5’-O-DMTr-2’-O-propargylguanosine-3’-CED-phosphoramidite

N2-iBu-5’-O-DMTr-2’-O-propargylguanosine-3’-CED-phosphoramidite

Item no.	HY-154351-5mg
Manufacturer	MedChem Express
CASRN	171486-61-6
Amount	5 mg
Quantity options	100 mg 10 mg 1 ea 250 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Citations	[1]Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.
Smiles	C#CCO[C@@H]1[C@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](COC(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)O[C@H]1N5C=NC6=C5N=C(NC(C(C)C)=O)NC6=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping condition	Room temperature
Available
Manufacturer - Type	Oligonucleotides
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Nucleoside Antimetabolite/Analog
Shipping Temperature	Room temperature
Molecular Weight	893.96
Product Description	N2-iBu-5’-O-DMTr-2’-O-propargylguanosine-3’-CED-phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) [1] .
Manufacturer - Research Area	Cancer
Solubility	10 mM in DMSO
Manufacturer - Pathway	Cell Cycle/DNA Damage
Clinical information	No Development Reported

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