« Back
Home /
A 438079

A 438079

Item no.	HY-15488-25mg
Manufacturer	MedChem Express
CASRN	899507-36-9
Amount	25 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.88
Citations	[1]McGaraughty S, et al. P2X7-related modulation of pathological nociception in rats. Neuroscience. 2007 Jun 8;146(4):1817-28.\|[2]Mesuret G, et al. CNS Neurosci Ther. 2014 Jun;20(6):556-64.\|[3]Marcellino D, et al. On the role of P2X(7) receptors in dopamine nerve cell degeneration in a rat model of Parkinson's disease: studies with the P2X(7) receptor antagonist A-438079. J Neural Transm (Vienna). 2010 Jun;117(6):681-7.\|[4]Martins JP, et al. The role of P2X7 purinergic receptors in inflammatory and nociceptive changes accompanying cyclophosphamide-induced haemorrhagic cystitis in mice. Br J Pharmacol. 2012 Jan;165(1):183-96. Brain, Behavior, and Immunity. 2020 Aug;88:507-514.\|Eur J Pharmacol. 2025 May 15.\|Front Mol Neurosci. 2018 Nov 6;11:401.\|Gen Physiol Biophys. 2019 Sep;38(5):407-416.\|Inflammation. 2024 Aug 17.\|Int J Mol Sci. 2022 May 17;23(10):5586.\|J Adv Res. 2024 Jul 15:S2090-1232(24)00298-4.\|Med Sci Monit. 2020 Sep 21;26:e925491. \|Neural Regen Res. 2021 Aug;16(8):1582-1591.\|Purinergic Signal. 2023 Mar 1.\|Purinergic Signal. 2024 Nov 16.\|Cancer Immunol Res. 2020 Nov;8(11):1426-1439.\|J Ethnopharmacol. 2024 Sep 7:118792.\|J Immunol. 2023 May 5;ji2200838.
Smiles	ClC1=C(Cl)C(C2=NN=NN2CC3=CC=CN=C3)=CC=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	P2X Receptor
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	306.15
Product Description	A 438079 is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.
Manufacturer - Research Area	Neurological Disease
Solubility	DMSO: 100 mg/mL (ultrasonic)\|H2O: 0.2 mg/mL (ultrasonic)
Manufacturer - Pathway	Membrane Transporter/Ion Channel
Isoform	P2X7 Receptor
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

HY-15488-25mg-safety-datasheet.pdf