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Mibefradil

Mibefradil

Item no.	HY-15553-1mg
Manufacturer	MedChem Express
CASRN	116644-53-2
Amount	1 mg
Quantity options	100 mg 10 mg 1 ea 1 mg 25 mg 50 mg 5 mg
Category	Cardiovascular Research Myocardial Infarction Hypertension Inhibitors & Compound Libraries Small Molecules Arrhythmias
Type	Inhibitors
Specific against	other
Citations	[1]Mehrke G, et al. The Ca(++)-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ channels. J Pharmacol Exp Ther. 1994 Dec;271(3):1483-8.\|[2]Brain KL, et al. The sources and sequestration of Ca(2+) contributing to neuroeffector Ca(2+) transients in the mouse vas deferens. J Physiol. 2003 Dec 1;553(Pt 2):627-35.\|[3]Yu YF, et al. Protection of the cochlear hair cells in adult C57BL/6J mice by T-type calcium channel blockers. Exp Ther Med. 2016 Mar;11(3):1039-1044.\|[4]Shiue SJ, et al. Chronic intrathecal infusion of T-type calcium channel blockers attenuates CaV3.2 upregulation in nerve-ligated rats. Acta Anaesthesiol Taiwan. 2016 Oct 17. pii: S1875-4597(16)30071-6. Biochem Biophys Res Commun. 2020 Feb 19;522(4):862-868.\|Br J Pharmacol. 2021 Jan;178(2):346-362.\|Eur J Pharmacol. 2021 Feb 5;892:173782.\|Front Pharmacol. 23 February 2022.\|J Cell Physiol. 2021 Mar 11.\|Mediat Inflamm. 2020 Nov 10;2020:3691701.\|Theriogenology. 2021 Jan 1;159:140-146.\|ACS Nano. 2024 Oct 31.\|Front Pharmacol. 2022 Feb 23;13:816133.\|PLoS Biol. 2024 Mar 25;22(3):e3002565.\|Res Sq. 2024 Jun 11.\|Small. 2024 Aug 10:e2403381.
Smiles	O=C(O[C@@]1(CCN(CCCC2=NC3=CC=CC=C3N2)C)[C@@H](C(C)C)C4=C(C=C(F)C=C4)CC1)COC
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Ro 40-5967
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Calcium Channel
Shipping Temperature	Room temperature
Molecular Weight	495.63
Product Description	Mibefradil (Ro 40-5967) is a calcium channel blocker with moderate selectivity for T-type Ca2+ channels displaying IC50s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively[1].
Manufacturer - Research Area	Cardiovascular Disease; Cancer
Solubility	10 mM in DMSO
Manufacturer - Pathway	Membrane Transporter/Ion Channel; Neuronal Signaling
Isoform	L-type calcium channel; T-type calcium channel
Clinical information	Launched

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