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Kobe2602

Kobe2602

Item no.	HY-15717-5mg
Manufacturer	MedChem Express
CASRN	454453-49-7
Amount	5 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 250 mg 25 mg 50 mg 5 mg
Category	Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.20
Citations	[1]Shima, Fumi, et al. In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proceedings of the National Academy of Sciences of the United States of America (2013), 110(20), 8182-8187, S8182/1-S8182/10.
Smiles	FC(C1=CC([N+]([O-])=O)=C(NNC(NC2=CC=C(F)C=C2)=S)C([N+]([O-])=O)=C1)(F)F
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Ras
Shipping Temperature	Blue Ice
Storage Conditions	-20°C, 3 years (Powder)
Molecular Weight	419.31
Product Description	Kobe2602 is a Ras-Raf interaction inhibitor. Kobe2602 inhibits the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki of 149 μM. Kobe2602 has antitumor activity[1].
Manufacturer - Research Area	Cancer
Solubility	DMSO: ≥ 250 mg/mL
Manufacturer - Pathway	GPCR/G Protein; MAPK/ERK Pathway
Clinical information	No Development Reported

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HY-15717-5mg-safety-datasheet.pdf