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NVS-STG2

NVS-STG2

Item no.	HY-157214-100mg
Manufacturer	MedChem Express
CASRN	3030588-01-0
Amount	100 mg
Quantity options	1 ea 100 mg 10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.76
Smiles	COC1=C(C=CC(C(O)=O)=C1)NCC2=CC=C(C=C2)C3(OCC(C)(CO3)C)C(C)(C)C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Molecular Glues; STING
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	427.53
Product Description	NVS-STG2 is a molecular glue that targets STING and activates STING-mediated immune signaling. NVS-STG2 induces higher-order oligomerization of human STING by binding to pockets between adjacent STING dimer transmembrane domains, effectively acting as a molecular glue. NVS-STGI enhances the activity of cGAMP by inducing the formation of more abundant and larger oligomers. NVS-STG2 produces antitumor activity in animal models [1] [2] .
Manufacturer - Research Area	cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Immunology/Inflammation; PROTAC
Clinical information	No Development Reported

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HY-157214-100mg-safety-datasheet.pdf