BQ-788

Item no.	HY-15894A-25mg
Manufacturer	MedChem Express
CASRN	173326-37-9
Amount	25 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Brain Cancer Nervous System Cancer
Type	Inhibitors
Specific against	other
Purity	98.66
Citations	[1]Okada M, et al. BQ-788, a selective endothelin ET(B) receptor antagonist. Cardiovasc Drug Rev. 2002 Winter;20(1):53-66.\|[2]Sargent CA, et al. Effect of endothelin antagonists with or without BQ 788 on ET-1 responses in pithed rats. J Cardiovasc Pharmacol. 1995;26 Suppl 3:S216-8.\|[3]Fattori V, et al. Differential regulation of oxidative stress and cytokine production by endothelin ETA and ETB receptors in superoxide anion-induced inflammation and pain in mice. J Drug Target. 2016 Oct 5:1-27 Cells. 2021, 10(11), 3072.\|Environ Pollut. 2016 Feb;209:11-20.\|Environ Pollut. 2016 Nov;218:487-496. \|J Exp Clin Cancer Res. 2025 Feb 21;44(1):64.\|Neurotherapeutics. 2021 Oct 18.\|Toxicol Sci. 2016 Jan;149(1):213-26.\|BMC Cancer. 2018 Feb 6;18(1):154.\|Environ Sci Pollut Res Int. 2018 May;25(15):14713-14725.\|J Neuroimmune Pharmacol. 2024 Apr 13;19(1):13.\|PLoS Pathog. 2020 Oct 19;16(10):e1008947.
Smiles	CCCC[C@H](C(O)=O)NC([C@@H](CC1=CN(C(OC)=O)C2=CC=CC=C12)NC([C@H](CC(C)(C)C)NC(N3[C@H](C)CCC[C@@H]3C)=O)=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Metabolism-sugar/lipid metabolism
Manufacturer - Targets	Endothelin Receptor
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, sealed storage, away from moisture)
Molecular Weight	641.80
Product Description	BQ-788 is a potent, selective ETB receptor antagonist with IC50 of 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells, poorly inhibiting the binding to ETA receptors in human neuroblastoma cell line SK-N-MC cells with IC50 of 1300 nM[1].
Manufacturer - Research Area	Cardiovascular Disease; Endocrinology; Cancer
Solubility	DMSO: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	GPCR/G Protein
Isoform	ETB
Clinical information	Phase 1

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HY-15894A-25mg-safety-datasheet.pdf