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Ceralasertib

Ceralasertib

Item no.	HY-19323-500mg
Manufacturer	MedChem Express
CASRN	1352226-88-0
Amount	500 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 g 1 mg 25 mg 500 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Breast Cancer
Type	Inhibitors
Specific against	other
Purity	99.76
Citations	[1]Vendetti FP, et al. The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of CDDP to resolve ATM-deficient non-small cell lung cancer in vivo.\|[2]Kim HJ, et al. Anti-tumor activity of the ATR inhibitor AZD6738 in HER2 positive breast cancer cells. Int J Cancer. 2017 Jan 1;140(1):109-119.
Smiles	O=[S@@](C1(CC1)C2=NC(C3=C4C(NC=C4)=NC=C3)=NC(N5CCOC[C@H]5C)=C2)(C)=N
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	AZD6738
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	ATM/ATR
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	412.51
Product Description	Ceralasertib (AZD6738) is an orally active and bioavailable inhibitor of ATR kinase with an IC50 of 1 nM.
Manufacturer - Research Area	Cancer
Solubility	DMSO: 70 mg/mL (ultrasonic)
Manufacturer - Pathway	Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Isoform	ATR
Clinical information	Phase 3

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HY-19323-500mg-safety-datasheet.pdf