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Paxalisib

Paxalisib

Item no.	HY-19962-25mg
Manufacturer	MedChem Express
CASRN	1382979-44-3
Amount	25 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 500 mg 50 mg 5 mg
Category	Neuroscience Neural Lineage Markers Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.63
Citations	[1]Heffron TP, et al. Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR. ACS Med Chem Lett. 2016 Feb 16;7(4):351-6.
Smiles	NC1=NC=C(C2=NC(N3CCOCC3)=C4N=C(C(C)(C)OCC5)N5C4=N2)C=N1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	GDC-0084
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	mTOR; PI3K
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	382.42
Product Description	Paxalisib (GDC-0084) is a brain penetrant inhibitor of PI3K and mTOR, with Kis of 2 nM, 46 nM, 3 nM, 10 nM and 70 nM for PI3Kα PI3Kβ, PI3Kδ, PI3Kγ and mTOR, respectively[1].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 7.69 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	PI3K/Akt/mTOR
Isoform	mTOR; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
Clinical information	Phase 3

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HY-19962-25mg-safety-datasheet.pdf