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Procainamide

Procainamide

Item no.	HY-A0084A-10mM
Manufacturer	MedChem Express
CASRN	51-06-9
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 1 ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	99.80
Citations	[1]Lee BH, et al. Procainamide is a specific inhibitor of DNA methyltransferase 1. J Biol Chem. 2005;280(49):40749-40756.\|[2]Pritchard B, et al. Procainamide. [Updated 2021 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-.\|[3]Gardner I, et al. A comparison of the covalent binding of clozapine, procainamide, and vesnarinone to human neutrophils in vitro and rat tissues in vitro and in vivo[J]. Chemical research in toxicology, 2005, 18(9): 1384-1394.\|[4]Nakahara T, et al. Involvement of K+ channel in procainamide-induced relaxation of bovine tracheal smooth muscle[J]. European journal of pharmacology, 2000, 402(1-2): 143-149.\|[5]Morissette G, et al. Massive cell vacuolization induced by organic amines such as procainamide[J]. Journal of Pharmacology and Experimental Therapeutics, 2004, 310(1): 395-406.\|[6]Segura-Pacheco B, et al. Reactivation of tumor suppressor genes by the cardiovascular drugs hydralazine and procainamide and their potential use in cancer therapy[J]. Clinical Cancer Research, 2003, 9(5): 1596-1603. Adv Sci (Weinh). 2024 Dec 5:e2410360.\|Environ Pollut. 2023 May 31;121931.\|Free Radic Biol Med. 2024 Jun 1:S0891-5849(24)00506-9.\|Clin Chem. 2019 Dec;65(12):1522-1531. \|Patent. US20180263995A1.
Smiles	O=C(NCCN(CC)CC)C1=CC=C(N)C=C1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Procaine amide,SP 100
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	DNA Methyltransferase; Potassium Channel
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Molecular Weight	235.33
Product Description	Procainamide (Procaine amide) is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1), which reactivates the expression of tumor suppressor factors by demethylating tumor suppressor genes. Procainamide induces vacuolization in various cell types and reduces cell proliferation and migration. Procainamide relaxes airway smooth muscle by activating potassium channels. Procainamide can be used in cancer and arrhythmia research[1][2][3][4][5][6].
Manufacturer - Research Area	Cancer; Cardiovascular Disease
Solubility	DMSO: 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Epigenetics; Membrane Transporter/Ion Channel
Clinical information	Launched

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HY-A0084A-10mM-safety-datasheet.pdf