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Chlorpromazine (hydrochloride)

Chlorpromazine (hydrochloride)

Item no.	HY-B0407A-100mg
Manufacturer	MedChem Express
CASRN	69-09-0
Amount	100 mg
Quantity options	100 mg 1 g 500 mg 5 g
Category	Food Safety Drugs Neuroscience Molecular Targets for Neuroscience Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.90
Citations	[1]Kamgar-Dayhoff P, et al. Multifaceted effect of chlorpromazine in cancer: implications for cancer treatment. Oncotarget. 2021 Jul 6;12(14):1406-1426. \|[2]Shin SY, et al. The antipsychotic agent chlorpromazine induces autophagic cell death by inhibiting the Akt/mTOR pathway in human U-87MG glioma cells. Carcinogenesis. 2013 Sep;34(9):2080-9. \|[3]Yang Z, et al. Cancer cell-intrinsic XBP1 drives immunosuppressive reprogramming of intratumoral myeloid cells by promoting cholesterol production. Cell Metab. 2022 Nov 2:S1550-4131(22)00461-2. \|[4]Lee SJ, et al. Mechanism of inhibition by chlorpromazine of the human pain threshold sodium channel, Nav1.7. Neurosci Lett. 2017 Feb 3;639:1-7. \|[5]Thomas D, et al. The antipsychotic drug chlorpromazine inhibits HERG potassium channels. Br J Pharmacol. 2003 Jun;139(3):567-74. \|[6]Suzuki H, et al. Comparison of the anti-dopamine D₂ and anti-serotonin 5-HT(2A) activities of chlorpromazine, bromperidol, haloperidol and second-generation antipsychotics parent compounds and metabolites thereof. J Psychopharmacol. 2013 Apr;27(4):396-400. ACS Nano. 2020 Nov 24;14(11):14698-14714.\|Adv Funct Mater. 2020, 2004940.\|Anal Chem. 2020 Sep 1;92(17):11921-11926.\|Antivir Res. 2020 Jun;178:104786.\|Arab J Chem. 2020, 13 (1): 2558-2567.\|Biomaterials. 13 January 2022, 121373.\|Br J Pharmacol. 2020 Aug;177(15):3473-3488. \|Cell Commun Signal. 2019 May 23;17(1):49\|Cell Commun Signal. 2020 Nov 4;18(1):176.\|Comput Struct Biotec. 2021;19:1933-1943.\|Emerg Microbes Infect. 2022 Dec;11(1):483-497.\|Environ Sci Technol. 2021 Feb 11.\|Front Cell Dev Biol. 18 March 2021.\|Front Cell Dev Biol. 2021 Jul 7;9:687322.\|Front Cell Dev Biol. 2023 Sep 8;11:1266198.\|Front Immunol. 2021 Aug 2;12:686846.\|Insect Sci. 2020 Aug;27(4):675-686.\|Int J Biol Macromol. 14 March 2022.\|J Am Chem Soc. 2018 Dec 12;140(49):17234-17240.\|Langmuir. 2020 Sep 29;36(38):11374-11382.\|mBio. 2025 Feb 18:e0378724.\|Nat Commun. 2025 Mar 10;16(1):2368.\|Pharmaceutics. 2024 Nov 21.\|Phytother Res. 2023 Mar 8.\|PLoS Negl Trop Dis. 2019 Aug 20;13(8):e0007681. \|Sci China Life Sci. 2021 May 27;1-21.\|Sci Total Environ. 2021, 146523.\|Theranostics. 2019 May 31;9(13):3732-3753.\|Theranostics. 2020 May 17;10(15):6581-6598. \|Theranostics. 2021 May 24;11(15):7308-7321.\|Toxins. 2021 Mar 2;13(3):184.\|Virus Res. 2020 Jan 15;276:197806.\|Viruses. 2021 May 31;13(6):1035.\|ACS Nano. 2023 Apr 14.\|Acta Biomater. 2024 Dec 25:S1742-7061(24)00776-1.\|Acta Pharm Sin B. 2024 Aug 17.\|Adv Funct Mater. 2023 Jan 15.\|Adv Funct Mater. 2024 Oct 31.\|Adv Mater. 2025 Jan 10:e2415030.\|Adv Sci (Weinh). 2023 Apr 24;e2207017.\|BBA-Gen Subjects. 2022: 130300.\|Biol Res. 2023 Mar 11;56(1):10.\|Br J Pharmacol. 2023 Feb 2.\|Cell Commun Signal. 2023 May 4;21(1):99.\|Cell Metab. 2022 Dec 6;34(12):2018-2035.e8.\|Cell Metab. 2024 Jun 18:S1550-4131(24)00189-X.\|Chem Eng J. 2024 Apr 15, 486 150125.\|Chem Eng J. 2024 Sep 1.\|Chem Mater. 2025 Jan 18.\|Commun Biol. 2022 Nov 14;5(1):1248.\|Drug Deliv Transl Res. 2023 Oct 3.\|Extracell Vesicle. 2025 Jun.\|J Control Release. 2024 Apr 24:370:140-151.\|J Control Release. 2024 Oct 26:S0168-3659(24)00725-9.\|J Control Release. 2025 Jan 8:379:45-58.\|J Extracell Vesicles. 2024 Dec;13(12):e70025.\|J Immunother Cancer. 2023 Jan;11(1):e005592.\|J Leukoc Biol. 2024 Jul 16:qiae159.\|J Med Chem. 2023 Dec 9.\|J Pharm Anal. 2025 Jan 3.\|J Virol. 2021 Sep 29;JVI0134521.\|Microbiol Res. 2023 May 30;273:127421.\|Nat Biomed Eng. 2024 Sep 13.\|Nat Nanotechnol. 2024 Aug 26.\|Pharm Biol. 2022 Dec;60(1):1679-1689.\|Research Square Preprint. 2024 Apr 22.\|Research Square Print. 2023 Mar 20.\|Sci China Life Sci. 2024 Sep 13.\|Virus Res. 2024 Oct 19:350:199485.
Smiles	CN(C)CCCN1C2=C(C=CC=C2)SC3=CC=C(Cl)C=C13.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	5-HT Receptor; Autophagy; Cytochrome P450; Dopamine Receptor
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	355.33
Product Description	Chlorpromazine hydrochloride is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine hydrochloride exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine hydrochloride also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine hydrochloride also can inhibit clathrin-mediated endocytosis[1][2][3][4][5].
Manufacturer - Research Area	Cancer; Neurological Disease; Cardiovascular Disease
Solubility	DMSO: ≥ 60 mg/mL\|H2O: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Autophagy; GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Isoform	5-HT2 Receptor
Clinical information	Launched

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