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Trifluoperazine (dihydrochloride)

Trifluoperazine (dihydrochloride)

Item no.	HY-B0532A-50mg
Manufacturer	MedChem Express
CASRN	440-17-5
Amount	50 mg
Quantity options	100 mg 10 mM/1 mL 500 mg 50 mg
Category	Food Safety Drugs Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.98
Citations	[1]Santofimia-Castaño P, et al. Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis. J Clin Invest. 2019;129(6):2500-2513. Published 2019 Mar 28.\|[2]Huerta-Bahena J, Villalobos-Molina R, García-Sáinz JA. Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergic effects. Mol Pharmacol. 1983;23(1):67-70.\|[3]Marques LO, Lima MS, Soares BG. Trifluoperazine for schizophrenia. Cochrane Database Syst Rev. 2004;2004(1):CD003545.\|[4]Howland RH. Trifluoperazine: A Sprightly Old Drug. J Psychosoc Nurs Ment Health Serv. 2016;54(1):20-22.\|[5]Ochiai H, et al. Influence of trifluoperazine on the late stage of influenza virus infection in MDCK cells. Antiviral Res. 1991;15(2):149-160. bioRxiv. 2024 June 12.\|BMC Med Genomics. 2024 Jan 2;17(1):12.\|CNS Neurosci Ther. 2023 Jan 10.\|Free Radic Biol Med. 2024 Nov 27:S0891-5849(24)01079-7.\|J Transl Med. 2024 Aug 1;22(1):715.\|Mol Med Rep. 2021 Mar 3.\|Chem Biol Interact. 2024 Feb 13:110904.\|Food Biosci. 2024 Feb, 57, 103513.
Smiles	FC(C(C=C1N2CCCN3CCN(C)CC3)=CC=C1SC4=C2C=CC=C4)(F)F.Cl.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Adrenergic Receptor; Autophagy; CaMK; Dopamine Receptor; Influenza Virus; P-glycoprotein
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	480.42
Product Description	Trifluoperazine dihydrochloride, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine dihydrochloride is a potent α1-adrenergic receptor antagonist. Trifluoperazine dihydrochloride is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine dihydrochloride is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine dihydrochloride can be used for the research of schizophrenia. Trifluoperazine dihydrochloride acts as a reversible inhibitor of influenza virus morphogenesis[1][2][3][4][5].
Manufacturer - Research Area	Neurological Disease; Cancer
Solubility	DMSO: 50 mg/mL (ultrasonic)\|H2O: 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Autophagy; GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Clinical information	Launched

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 mg

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