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Metamizole (sodium hydrate)

Metamizole (sodium hydrate)

Item no.	HY-B1279-10g
Manufacturer	MedChem Express
CASRN	5907-38-0
Amount	10 g
Quantity options	10 g 10 mMx1 mL 1 g 500 mg 5 g
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.89
Citations	[1]Pierre SC, et al. Inhibition of cyclooxygenases by dipyrone. Br J Pharmacol. 2007 Jun;151(4):494-503.\|[2]De Luna-Bertos E, et al. Therapeutic doses of nonsteroidal anti-inflammatory drugs inhibit osteosarcoma MG-63 osteoblast-like cells maturation, viability, and biomineralization potential. ScientificWorldJournal. 2013 Sep 19;2013:809891.\|[3]Malsy M, et al. Effects of metamizole, MAA, and paracetamol on proliferation, apoptosis, and necrosis in the pancreatic cancer cell lines PaTu 8988 t and Panc-1. BMC Pharmacol Toxicol. 2017 Dec 6;18(1):77.\|[4]Zajaczkowska R, et al. Metamizole relieves pain by influencing cytokine levels in dorsal root ganglia in a rat model of neuropathic pain. Pharmacol Rep. 2020 Oct;72(5):1310-1322.\|[5]Ince I, Aksoy M, et al. A Comparative Investigation of the Analgesic Effects of Metamizole and Paracetamol in Rats. J Invest Surg. 2015 Jun;28(3):173-80. Animal Model Exp Med. 2024 Jan 15.\|Animal Model Exp Med. 2024 Jan 15.
Smiles	O=S(CN(C1=C(C)N(C)N(C2=CC=CC=C2)C1=O)C)(O[Na])=O.O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Dipyrone (hydrate),Methamizole (sodium hydrate)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Apoptosis; COX
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, stored under nitrogen)
Molecular Weight	351.35
Product Description	Metamizole sodium hydrate (Dipyrone) is an orally active cyclooxygenase (COX) inhibitor.. Metamizole sodium hydrate can inhibit cell proliferation and promote cell apoptosis. Metamizole sodium hydrate has anti-inflammatory and antioxidant activities. Metamizole sodium hydrate is an antipyretic, analgesic and spasmolytic agent. Metamizole sodium hydrate can be used in research to relieve a variety of pain[1][2][3][4][5].
Manufacturer - Research Area	Inflammation/Immunology
Solubility	DMSO: 100 mg/mL (ultrasonic)\|H2O: ≥ 100 mg/mL
Manufacturer - Pathway	Apoptosis; Immunology/Inflammation
Clinical information	Launched

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HY-B1279-10g-safety-datasheet.pdf