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Phosphocreatine

Phosphocreatine

Item no.	HY-D0885-5g
Manufacturer	MedChem Express
CASRN	67-07-2
Amount	5 g
Quantity options	100 mg 10 g 10 mg 1 ea 1 g 25 mg 500 mg 5 g 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	95.0
Citations	[1]Feldman EB, et al. Creatine: a dietary supplement and ergogenic aid. Nutr Rev. 1999 Feb;57(2):45-50.\|[2]Wang C, et al. Phosphocreatine attenuates doxorubicin-induced cardiotoxicity by inhibiting oxidative stress and activating TAK1 to promote myocardial survival in vivo and in vitro. Toxicology. 2021 Aug;460:152881. \|[3]Li H, et al. Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways. Free Radic Biol Med. 2018 May 20;120:228-238. \|[4]Shopit A, et al. Protection of diabetes-induced kidney injury by phosphocreatine via the regulation of ERK/Nrf2/HO-1 signaling pathway. Life Sci. 2020 Feb 1;242:117248.
Smiles	O=C(O)CN(C(NP(O)(O)=O)=N)C
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Creatine phosphate,Creatinephosphoric acid
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Targets	Akt; Apoptosis; Endogenous Metabolite; ERK; MAP3K; Mitochondrial Metabolism; ROS Kinase
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	211.11
Product Description	Phosphocreatine (creatine phosphate) is an organic compound found in vertebrate skeletal muscles. Phosphocreatine enhances antioxidant activity, and activates the TAK1 pathway to protect the heart. Phosphocreatine normalizing mitochondrial function and reducing oxidative stress via Akt mediated Nrf2/HO-1 pathway. Phosphocreatine provides renal protection by suppressing Apoptosis and ROS (Reactive Oxygen Species) generation through ERK mediated mediated Nrf-2/HO-1 pathway.[1][2][3][4].
Manufacturer - Research Area	Metabolic Disease
Solubility	H2O: 175 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; MAPK/ERK Pathway; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Isoform	Human Endogenous Metabolite
Clinical information	Phase 3

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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