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Piperine

Piperine

Item no.	HY-N0144-100g
Manufacturer	MedChem Express
CASRN	94-62-2
Amount	100 g
Quantity options	100 g 10 g 10 mM/1 mL 1 g 200 mg 25 g 50 g 5 g
Category	Oncology Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer Colorectal Cancer
Type	Inhibitors
Specific against	other
Purity	98.94
Citations	[1]Paarakh PM, et al. In vitro cytotoxic and in silico activity of piperine isolated from Piper nigrum fruits Linn. In Silico Pharmacol. 2015 Dec;3(1):9. Epub 2015 Oct 29.\|[2]Meghwal M,et al. Piper nigrum and piperine: an update. Phytother Res. 2013 Aug;27(8):1121-30.\|[3]Li C, et al. Non-linear pharmacokinetics of piperine and its herb-drug interactions with docetaxel in Sprague-Dawley rats. J Pharm Biomed Anal. 2016 Sep 5;128:286-93.\|[4]Zhai WJ, et al. Piperine Plays an Anti-Inflammatory Role in Staphylococcus aureus Endometritis by Inhibiting Activation of NF-κB and MAPK Pathways in Mice. Evid Based Complement Alternat Med. 2016;2016:8597208.
Smiles	O=C(N1CCCCC1)/C=C/C=C/C2=CC=C(OCO3)C3=C2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Bioperine,1-Piperoylpiperidine
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Autophagy; Endogenous Metabolite; P-glycoprotein
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	285.34
Product Description	Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC50 of 61.94±0.054 μg/mL[1][2][3].
Manufacturer - Research Area	Inflammation/Immunology; Cancer
Solubility	DMSO: 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Autophagy; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Clinical information	Phase 2

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HY-N0144-100g-safety-datasheet.pdf