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Isofraxidin

Isofraxidin

Item no.	HY-N0774-100mg
Manufacturer	MedChem Express
CASRN	486-21-5
Amount	100 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 20 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.93
Citations	[1]Yamazaki T, et al. Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits matrix metalloproteinase-7 expression and cell invasion of human hepatoma cells.Biol Pharm Bull. 2010;33(10):1716-22.\|[2]Jin J , et al. Isofraxidin targets the TLR4/MD-2 axis to prevent osteoarthritis development.Food Funct. 2018 Nov 14;9(11):5641-5652.
Smiles	O=C1C=CC2=CC(OC)=C(O)C(OC)=C2O1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	COX; ERK; MMP; Toll-like Receptor (TLR)
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	222.19
Product Description	Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells[1]. Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation[2].
Manufacturer - Research Area	Inflammation/Immunology
Solubility	DMSO: 250 mg/mL (ultrasonic)
Manufacturer - Pathway	Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Stem Cell/Wnt
Isoform	COX-2; MMP-7; TLR4
Clinical information	No Development Reported

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HY-N0774-100mg-safety-datasheet.pdf