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Protopine

Protopine

Item no.	HY-N0793-25mg
Manufacturer	MedChem Express
CASRN	130-86-9
Amount	25 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Signaling By Cell Type Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer Colorectal Cancer Breast Cancer
Type	Inhibitors
Specific against	other
Purity	99.81
Citations	[1]Kim SR, et, al. Protopine from Corydalis ternata has anticholinesterase and antiamnesic activities. Planta Med. 1999 Apr;65(3):218-21. \|[2]Nie C, et, al. Protopine triggers apoptosis via the intrinsic pathway and regulation of ROS/PI3K/Akt signalling pathway in liver carcinoma. Cancer Cell Int. 2021 Jul 27;21(1):396.\|[3]Xu LF, et al. Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models. Neuropharmacology. 2006 Jun;50(8):934-40. \|[4]Xiao X, et al. Protective effect of protopine on the focal cerebral ischaemic injury in rats. Basic Clin Pharmacol Toxicol. 2007 Aug;101(2):85-9.
Smiles	O=C1CC2=CC=C3C(OCO3)=C2CN(C)CCC4=CC5=C(OCO5)C=C41
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Corydinine
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Cholinesterase (ChE)
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	353.37
Product Description	Protopine (Corydinine), an isoquinoline alkaloid, is a specific reversible and competitive inhibitor of acetylcholinesterase. Protopine exhibits anti-inflammation, anti-microbial, anti-angiogenic and anti-tumour activity[1][2].
Manufacturer - Research Area	Cancer; Infection; Inflammation/Immunology; Neurological Disease
Solubility	DMSO: 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Neuronal Signaling
Clinical information	No Development Reported

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HY-N0793-25mg-safety-datasheet.pdf