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Halofuginone (hydrobromide)

Halofuginone (hydrobromide)

Item no.	HY-N1584A-100mg
Manufacturer	MedChem Express
CASRN	64924-67-0
Amount	100 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 25 mg 500 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.99
Citations	[1]Tsuchida K, et al. Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation. Free Radic Biol Med. 2017 Feb;103:236-247.\|[2]Keller TL, et al. Halofuginone and other Febrifugine derivatives inhibit prolyl-tRNA synthetase. Nat Chem Biol. 2012 Feb 12;8(3):311-7.\|[3]Cui Z, et al. Halofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone. Ann Rheum Dis. 2016 Sep;75(9):1714-21.\|[4]Tracy L McGaha, et al. Halofuginone, an inhibitor of type-I collagen synthesis and skin sclerosis, blocks transforming-growth-factor-beta-mediated Smad3 activation in fibroblasts. J Invest Dermatol. 2002 Mar;118(3):461-70.\|[5]Pritesh P Jain, et al. Halofuginone, a Promising Drug for Treatment of Pulmonary Hypertension. Br J Pharmacol. 2021 Mar 10. Hum Gene Ther. 2021 Aug 18.\|ACS Infect Dis. 2023 Mar 15.\|Br J Pharmacol. 2021 Mar 10.\|Cell Metab. 2023 Nov 11:S1550-4131(23)00385-6.\|Fish Shellfish Immunol. 2024 Jun 25:109727.\|Friedrich-Alexander University Erlangen-Nuremberg. 2023 May 2.\|Indian J Hematol Blood Transfus. 2024 Mar 25.\|iScience. 2023 Mar.\|J Funct Foods. 2024 Jul.\|J Tissue Eng Regen Med. 2021 Aug 7.\|Photodiagnosis Photodyn Ther. 2021 Oct 7;102572.
Smiles	O=C1N(CC(C[C@@H]2NCCC[C@H]2O)=O)C=NC3=C1C=C(Cl)C(Br)=C3.Br
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	RU-19110 (hydrobromide)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	COVID-19-anti-virus
Manufacturer - Targets	Calcium Channel; DNA/RNA Synthesis; Parasite; Sodium Channel; TGF-beta/Smad
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	495.59
Product Description	Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM[1][2]. Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity[3][4]. Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects[5].
Manufacturer - Research Area	Cancer; Infection; Inflammation/Immunology; Cardiovascular Disease
Solubility	DMSO: 50 mg/mL (ultrasonic)\|H2O: 2.6 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Neuronal Signaling; Stem Cell/Wnt; TGF-beta/Smad
Isoform	Plasmodium
Clinical information	Phase 2

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HY-N1584A-100mg-safety-datasheet.pdf