LDN-193189 2HCl

Item no.	S7507-10mM/1mL
Manufacturer	Selleckchem
CASRN	1435934-00-1
Amount	10 mM/1 mL
Quantity options	10 mg 10 mM/1 mL 1 g 5 mg 50 mg
Category	Neuroscience Molecular Targets for Neuroscience Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Smiles	C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3.Cl.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	DM-3189 2HCl
Available
Storage Conditions	2 years -80 in solvent
Information	LDN-193189 (DM3189) 2HCl is a selective BMP signaling inhibitor, inhibits the ALK1, ALK2, ALK3 and ALK6 with IC50s of 0.8 nM, 0.8 nM, 5.3 nM and 16.7 nM in the kinase assay, respectively. LDN-193189 inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50s of 5 nM and 30 nM in C2C12 cells, respectively, exhibits 200-fold selectivity for BMP versus TGF-β.

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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S7507-10mM/1mL-datasheet.pdf

S7507-10mM/1mL-safety-datasheet.pdf