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PIM447 (LGH447) Hydrochloride

PIM447 (LGH447) Hydrochloride

Item no.	S7985-10mM/1mL
Manufacturer	Selleckchem
CASRN	1210608-43-7(freebase)
Amount	10 mM/1 mL
Quantity options	10 mM/1 mL 2 mg 5 mg
Category	Metabolism Diabetes Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Smiles	CC1CC(CC(C1)N)C2=C(C=NC=C2)NC(=O)C3=NC(=C(C=C3)F)C4=C(C=CC=C4F)F
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Storage Conditions	2 years -80 in solvent
Information	PIM447 (LGH447) Hydrochloride is a novel pan-PIM kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively. It also inhibits GSK3β, PKN1, and PKCτ, but at a significantly lower potency with IC50 between 1 and 5 μM (>105-fold differential relative to the Ki on PIMs). PIM447 induces apoptosis.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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S7985-10mM/1mL-datasheet.pdf

S7985-10mM/1mL-safety-datasheet.pdf