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CCR6 inhibitor 1

CCR6 inhibitor 1

Item no.	CS-0062823-10mg
Manufacturer	ChemScene
Amount	10mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Purity	>98%
Formula	C24H23F3N4O3S
MWt	504.52
Solubility	DMSO : >= 125 mg/mL (247.76 mM)
Clinical Information	No Development Reported
Pathway	Immunology/Inflammation; GPCR/G Protein
Target	CCR; CCR
Biological Activity	CCR6 inhibitor 1 is a potent and selective CCR6 inhibitor, with IC₅₀s of 0.45 and 6 nM for monkey and human CCR6, much more selective at CCR6 over human CCR1 (IC₅₀, > 30000 nM), and CCR7 (IC₅₀, 9400 nM). CCR6 inhibitor 1 markedly blocks ERK phosphorylation. CCR6 inhibitor 1 is used in the research of autoimmune diseases and cancer^[1]. IC50 & Target: IC50: 0.45 nM (Moneky CCR6), 6 nM (Human CCR6), 9400 nM (Human CCR7)^[1] In Vitro: CCR6 inhibitor 1 (Compound 35) inhibits L20-induced human B cell migration^[1].

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10mg

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Delivery expected until 10/2/2025

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