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HDACs/mTOR Inhibitor 1

HDACs/mTOR Inhibitor 1

Item no.	CS-0084988-50mg
Manufacturer	ChemScene
Amount	50mg
Category	Oncology By Cell Type Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Cell Biology Cell Status Autophagy Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Similar products	2271413-06-8
Available
CAS	2271413-06-8
Purity	>98%
Formula	C28H38N8O5
MWt	566.65
Solubility	DMSO : 32.5 mg/mL (57.35 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Apoptosis; PI3K/Akt/mTOR; Epigenetics; Cell Cycle/DNA Damage
Target	Apoptosis; mTOR; HDAC; HDAC
Biological Activity	HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies, with IC₅₀s of 0.19 nM, 1.8 nM, 1.2 nM and >500 nM for HDAC1, HDAC6, mTOR and PI3Kalpha, respectively. HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in G0/G1 phase and induce tumor cell apoptosis with low toxicity in vivo^[1]. IC50 & Target: IC50: 0.19 nM (HDAC1), 1.8 nM (HDAC6), 1.2 nM (mTOR), >500 nM (PI3Kalpha)^[1].

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50mg

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