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K-Ras(G12C) inhibitor 12

K-Ras(G12C) inhibitor 12

Item no.	CS-5104-50mg
Manufacturer	ChemScene
Amount	50mg
Category	Oncology By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Adenocarcinoma Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Colorectal Cancer
Type	Inhibitors
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Similar products	1469337-95-8
Available
CAS	1469337-95-8
Purity	>98%
Formula	C15H17ClIN3O3
MWt	449.67
Solubility	DMSO : >= 48 mg/mL (106.74 mM)
Clinical Information	No Development Reported
Pathway	GPCR/G Protein
Target	Ras
Biological Activity	K-Ras(G12C) inhibitor 12 is a K-Ras(G12C) inhibitor, the half-maximum effective concentration (EC50) for K-Ras(G12C) inhibitor 12 in H1792 cells is 0.32 uM. IC50 value: 0.32 uM (EC50) Target: K-Ras Binding of K-Ras(G12C) inhibitor 12 to K-Ras(G12C) disrupts both switch-I and switch-II, subverting the native nucleotide preference to favour GDP over GTP and impairing binding to Raf. In the absence of K-Ras(G12C) inhibitor 12, K-Ras(G12C) shows a slight preference for GTP (relative affinity 0.6).

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50mg

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