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Thailanstatin A

Thailanstatin A

Item no.	DCC-DC45695-10mg
Manufacturer	DCChemicals
CASRN	1426953-21-0
Amount	10 mg
Quantity options	10 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Applications	other
Specific against	other
Smiles	CC(=O)OC(C)\C=C\C(=O)NC1C(C)OC(C\C=C(/C)\C=C\C2C(O)C3(CC(CC(O)=O)O2)OC3)C(C)C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Manufacturer - Applications	Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC.
Molecular Weight	535, 62644

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 mg

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Delivery expected until 12/4/2025

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