M3258

Item no.	DCC-DC70579-100mg
Manufacturer	DCChemicals
CASRN	2285330-15-4
Amount	100 mg
Quantity options	100 mg 10 mg
Category	In Vivo Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Applications	other, IV
Specific against	other
Smiles	O1[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])[C@]([H])(C(N([H])[C@]([H])(B(O[H])O[H])C([H])([H])C1=C([H])OC3=C([H])C([H])=C([H])C([H])=C13)=O)C2([H])[H]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Manufacturer - Applications	M3258 (M 3258) is a potent, reversible, highly selective and orally acitve LMP7 inhibitor with ceullar IC50 of 4.1 nM.M3258 does not inhibit other constitutive proteasome and immunoproteasome subunits (IC50>2.5 uM).M3258 demonstrated strong antitumor efficacy in multiple myeloma xenograft models.M3258 treatment led to a significant and prolonged suppression of tumor LMP7 activity and ubiquitinated protein turnover and the induction of apoptosis in multiple myeloma cells both in vitro and in vivo.M3258 showed superior antitumor efficacy in selected multiple myeloma and mantle cell lymphoma xenograft models compared with the approved nonselective proteasome inhibitors bortezomib and ixazomib.
Molecular Weight	329, 1554

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Amount: 100 mg

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Delivery expected until 12/11/2025

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