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A-205804

A-205804

Item no.	HY-100226-10mg
Manufacturer	MedChem Express
CASRN	251992-66-2
Amount	10 mg
Quantity options	10 mM/1 mL 10 mg 1 mg 50 mg 5 mg
Category	Cardiovascular Research Thrombosis & Hemostasis Atherosclerosis Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.25
Citations	[1]Stewart AO, et al. Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM-1 and E-selectin expression. J Med Chem. 2001 Mar 15;44(6):988-1002.\|[2]Morita K, et al. RUNX transcription factors potentially control E-selectin expression in the bone marrow vascular niche in mice. Blood Adv. 2018 Mar 13;2(5):509-515.
Smiles	O=C(C(S1)=CC2=C1C=NC=C2SC3=CC=C(C)C=C3)N
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	251992-66-2
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Integrin
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	300.41
Product Description	A-205804 is an orally bioavailable, potent and selective lead inhibitor of E-selectin and ICAM-1 expression, with an IC50 of 20 nM and 25 nM for E-selectin and ICAM-1, respectively. A-205804 can be used in the research of chronic inflammatory diseases[1].
Manufacturer - Research Area	Inflammation/Immunology
Solubility	DMSO: 100 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Cytoskeleton
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-100226-10mg-safety-datasheet.pdf