CORM-3

Item no.	HY-100581-10mg
Manufacturer	MedChem Express
CASRN	475473-26-8
Amount	10 mg
Quantity options	10 mM/1 mL 10 mg 1 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	97.0
Citations	[1]Foresti R, et al. Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule. Br J Pharmacol. 2004 Jun;142(3):453-60.\|[2]Lee DW, et al. Carbon monoxide regulates glycolysis-dependent NLRP3 inflammasome activation in macrophages. Biochem Biophys Res Commun. 2017 Nov 18;493(2):957-963.\|[3]Huang Y, et al. Carbon monoxide (CO) inhibits hydrogen peroxide (H2O2)-induced oxidative stress and the activation of NF-κB signaling in lens epithelial cells. Exp Eye Res. 2018 Jan;166:29-39.
Smiles	O#C[Ru+2](C#O)([Cl-])([O-]C1=O)([N]([H])([H])C1)C#O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	NF-κB; NOD-like Receptor (NLR)
Shipping Temperature	Blue Ice
Storage Conditions	-20°C, 3 years (Powder)
Molecular Weight	294.61
Product Description	CORM-3, a carbon monoxide-releasing molecule, attenuates NF-κB p65 nuclear translocation, reduces ROS generation and enhances intracellular glutathione and superoxide dismutase levels. CORM-3 reduces NLRP3 inflammasome activation[1][2][3].
Manufacturer - Research Area	Inflammation/Immunology
Solubility	DMSO: 75 mg/mL (ultrasonic)
Manufacturer - Pathway	Immunology/Inflammation; NF-κB
Isoform	NLRP3
Clinical information	No Development Reported

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HY-100581-10mg-safety-datasheet.pdf