BMS453

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	50mg
Item no.	HY-100608-50mg
CASRN	166977-43-1
Available
Product Description	BMS453 (BMS-189453), a synthetic retinoid, is a RARβ agonist and a RARα/RARγ antagonist. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ.
StorageTemperature	-20°C, stored under nitrogen; In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Applications	Cancer-Kinase/protease
Formula	C27H24O2
References	[1].J Y Chen, et al. RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation. EMBO J. 1995 Mar 15; 14(6):1187-97. \| [2].L Yang, et al. The retinoic acid receptor antagonist, BMS453, inhibits normal breast cell growth by inducing active TGFbeta and causing cell cycle arrest. Oncogene. 2001 Nov 29; 20(55):8025-35.
MolecularWeight	380.48
Research Area	Cancer
Solubility	DMSO : 16.67 mg/mL (43.81 mM; ultrasonic and warming and heat to 60°C)
Target	RAR/RXR
Pathway	Metabolic Enzyme/Protease

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Amount: 50mg

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Delivery expected until 4/13/2023

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