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T16Ainh-A01

T16Ainh-A01

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	100mg
Item no.	HY-100612-100mg
CASRN	552309-42-9
Available
Product Description	T16Ainh-A01, an aminophenylthiazole, is a potent transmembrane protein 16A (TMEM16A) inhibitor, inhibiting TMEM16A-mediated chloride currents with an IC50 value of ~1 µM. TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC).
StorageTemperature	Powder -20°C 3 years; In solvent -80°C 6 months, -20°C 1 month
Formula	C19H20N4O3S2
References	[1].Fedigan S, et al. Effects of new-generation TMEM16A inhibitors on calcium-activated chloride currents in rabbit urethral interstitial cells of Cajal. Pflugers Arch. 2017 Nov; 469(11):1443-1455. \| [2].Namkung W, et al. TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J Biol Chem. 2011 Jan 21; 286(3):2365-74.
MolecularWeight	416.52
Research Area	Others
Solubility	DMF : ≥ 10 mg/mL (24.01 mM) \| DMSO : ≥ 5 mg/mL (12.00 mM)
Target	Chloride Channel
Pathway	Membrane Transporter/Ion Channel

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Amount: 100mg

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Delivery expected until 4/20/2023

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