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PPADS (tetrasodium)

PPADS (tetrasodium)

Item no.	HY-101044-1mg
Manufacturer	MedChem Express
CASRN	192575-19-2
Amount	1 mg
Quantity options	10 mM/1 mL 10 mg 1 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	95.0
Citations	[1]Flores-Soto E, et al. PPADS, a P2X receptor antagonist, as a novel inhibitor of the reverse mode of the Na⁺/Ca²⁺ exchanger in guinea pig airway smooth muscle. Eur J Pharmacol. 2012 Jan 15;674(2-3):439-44.\|[2]Huo H, et al. Mapping the binding site of the P2X receptor antagonist PPADS reveals the importance of orthosteric site charge and the cysteine-rich head region. J Biol Chem. 2018 Aug 17;293(33):12820-12831.\|[3]Einfluss von ATP und seinen Derivaten auf die Aktivierung von Monozyten.\|[4]Rost S, et al. P2 receptor antagonist PPADS inhibits mesangial cell proliferation in experimental mesangialproliferative glomerulonephritis. Kidney Int. 2002 Nov;62(5):1659-71. bioRxiv. 2024 November 03.\|J Biol Chem. 2021 Sep 3;101166.\|J Endocrinol Invest. 2024 Nov 11.\|Mil Med Res. 2024 Jun 27;11(1):41.\|ACS Chem Neurosci. 2025 Feb 5;16(3):374-383. \|bioRxiv. 2023 Sep 17.
Smiles	O=S(C1=CC=C(/N=N/C2=NC(C)=C(O)C(C=O)=C2COP(O[Na])(O[Na])=O)C(S(=O)(O[Na])=O)=C1)(O[Na])=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	192575-19-2
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Na+/Ca2+ Exchanger; P2X Receptor
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, sealed storage, away from moisture)
Molecular Weight	599.30
Product Description	PPADS tetrasodiuma is a non-selective P2X receptor antagonist. PPADS tetrasodiuma blocks recombinant P2X1, -2, -3, -5 with IC50s ranging from 1 to 2.6 μM. PPADS tetrasodiuma blocks native P2Y2-like (IC50~0.9 mM) and recombinant P2Y4 (IC50~15 mM) receptors. PPADS tetrasodiuma is an inhibitor of the reverse mode of the Na/Ca2+ exchanger in guinea pig airway smooth muscle[1][2].
Manufacturer - Research Area	Neurological Disease
Solubility	H2O: 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Membrane Transporter/Ion Channel
Isoform	P2X1 Receptor
Clinical information	No Development Reported

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HY-101044-1mg-safety-datasheet.pdf