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Zinc Protoporphyrin

Zinc Protoporphyrin

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	10mM*1mL
Item no.	HY-101193-10mM*1mL
CASRN	15442-64-5
Available
Product Description	Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2. Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration. Zinc Protoporphyrin has anti-cancer activity.
StorageTemperature	-20°C, sealed storage, away from moisture; In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Applications	COVID-19-immunoregulation
Formula	C34H32N4O4Zn
References	[1].Park C, et al. Protective Effect of Phloroglucinol on Oxidative Stress-Induced DNA Damage and Apoptosisthrough Activation of the Nrf2/HO-1 Signaling Pathway in HaCaT Human Keratinocytes. Mar Drugs. 2019 Apr 13; 17(4). \| [2].Mwangi MN, et al. Diagnostic utility of zinc protoporphyrin to detect iron deficiency in Kenyan pregnant women. BMC Med. 2014 Nov 26; 12:229. \| [3].Nowis D, et al. Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice. BMC Cancer. 2008 Jul 11; 8:197.
MolecularWeight	626.02
Research Area	Cancer; Metabolic Disease; Cardiovascular Disease
Solubility	DMSO : 20.83 mg/mL (33.27 mM; ultrasonic and warming and heat to 80°C) \| 0.2 M NaOH : 2.5 mg/mL (3.99 mM; ultrasonic and adjust pH to 14 with NaOH)
Target	Reactive Oxygen Species; Endogenous Metabolite; Apoptosis
Isoform	Human Endogenous Metabolite
Pathway	Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Apoptosis

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Amount: 10mM*1mL

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Delivery expected until 4/13/2023

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