Comparison

Zinc Protoporphyrin European Partner

Manufacturer MedChem Express
Category
Type Inhibitors
Specific against other
Amount 10mM*1mL
Item no. HY-101193-10mM*1mL
CASRN 15442-64-5
Available
Product Description
Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2. Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration. Zinc Protoporphyrin has anti-cancer activity.
StorageTemperature
-20°C, sealed storage, away from moisture; In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Applications
COVID-19-immunoregulation
Formula
C34H32N4O4Zn
References
[1].Park C, et al. Protective Effect of Phloroglucinol on Oxidative Stress-Induced DNA Damage and Apoptosisthrough Activation of the Nrf2/HO-1 Signaling Pathway in HaCaT Human Keratinocytes. Mar Drugs. 2019 Apr 13; 17(4). | [2].Mwangi MN, et al. Diagnostic utility of zinc protoporphyrin to detect iron deficiency in Kenyan pregnant women. BMC Med. 2014 Nov 26; 12:229. | [3].Nowis D, et al. Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice. BMC Cancer. 2008 Jul 11; 8:197.
MolecularWeight
626.02
Research Area
Cancer; Metabolic Disease; Cardiovascular Disease
Solubility
DMSO : 20.83 mg/mL (33.27 mM; ultrasonic and warming and heat to 80°C) | 0.2 M NaOH : 2.5 mg/mL (3.99 mM; ultrasonic and adjust pH to 14 with NaOH)
Target
Reactive Oxygen Species; Endogenous Metabolite; Apoptosis
Isoform
Human Endogenous Metabolite
Pathway
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Apoptosis

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

Amount: 10mM*1mL
Available: In stock
available

Delivery expected until 4/13/2023 

Compare

Add to wishlist

Request delivery time

Ask a technical question

Submit a bulk request

Questions about this Product?
 
Close