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Zinc Protoporphyrin

Zinc Protoporphyrin

Item no.	HY-101193-10mM*1mL
Manufacturer	MedChem Express
CASRN	15442-64-5
Amount	10 mM x 1 mL
Quantity options	10 mM/1 mL 10 mM x 1 mL 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.87
Citations	[1]Park C, et al. Protective Effect of Phloroglucinol on Oxidative Stress-Induced DNA Damage and Apoptosisthrough Activation of the Nrf2/HO-1 Signaling Pathway in HaCaT Human Keratinocytes. Mar Drugs. 2019 Apr 13;17(4). [2]Mwangi MN, et al. Diagnostic utility of zinc protoporphyrin to detect iron deficiency in Kenyan pregnant women. BMC Med. 2014 Nov 26;12:229. [3]Nowis D, et al. Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice. BMC Cancer. 2008 Jul 11;8:197.
Smiles	OC(CCC1=C(C=C2[N]3=C4C(C)=C2CCC(O)=O)[N-]([Zn+2]35[N]6=C7C=C(C(C=C)=C8C)[N-]5C8=C4)C(C=C6C(C=C)=C7C)=C1C)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Zn(II)-protoporphyrin IX, ZnPP, Zinc Protoporphyrin-9
Shipping condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Apoptosis; Endogenous Metabolite; Reactive Oxygen Species
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, sealed storage, away from moisture)
Molecular Weight	626.02
Product Description	Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2[1]. Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration[2]. Zinc Protoporphyrin has anti-cancer activity[3].
Manufacturer - Research Area	Cancer; Metabolic Disease; Cardiovascular Disease
Solubility	DMSO : 20.83 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Isoform	Human Endogenous Metabolite
Clinical information	No Development Reported

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HY-101193-10mM*1mL-safety-datasheet.pdf