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Otenzepad

Otenzepad

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	50mg
Item no.	HY-101381-50mg
CASRN	102394-31-0
Available
Product Description	Otenzepad (AF-DX 116) is a selective and competitive M2 muscarinic acetylcholine receptor antagonist, with IC50 values of 640 nM and 386 nM for rabbit peripheral lung and rat heart, respectively.
StorageTemperature	Powder -20°C 3 years, 4°C 2 years; In solvent -80°C 6 months, -20°C 1 month
Applications	Metabolism-sugar/lipid metabolism
Formula	C24H31N5O2
References	[1].Bloom JW, et al. Heterogeneity of the M1 muscarinic receptor subtype between peripheral lung and cerebral cortex demonstrated by the selective antagonist AF-DX 116. Life Sci. 1987 Jul 27; 41(4):491-6. \| [2].Packard MG, et al. Post-training injection of the acetylcholine M2 receptor antagonist AF-DX 116 improves memory. Brain Res. 1990 Jul 30; 524(1):72-6. \| [3].Kopf SR, et al. AF-DX 116, a presynaptic muscarinic receptor antagonist, potentiates the effects of glucose and reverses the effects of insulin on memory. Neurobiol Learn Mem. 1998 Nov; 70(3):305-13.
MolecularWeight	421.54
Research Area	Metabolic Disease; Neurological Disease
Solubility	DMSO : 25 mg/mL (59.31 mM; ultrasonic and warming and heat to 60°C)
Target	mAChR
Pathway	GPCR/G Protein; Neuronal Signaling

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