Comparison

HBX 41108 European Partner

Manufacturer MedChem Express
Category
Type Inhibitors
Specific against other
Amount 50mg
Item no. HY-101666-50mg
CASRN 924296-39-9
Available
Product Description
HBX 41108 is an uncompetitive inhibitor of ubiquitin-specific protease 7 (USP7) with an IC50 of 424 nM. HBX 41108 inhibits USP7-mediated p53 deubiquitination to stabilize p53 and inhibits cancer cell growth. HBX 41108 induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines.
StorageTemperature
4°C, sealed storage, away from moisture; In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Applications
Cancer-programmed cell death
Formula
C13H3ClN4O
References
[1].Colland F, et al. Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol Cancer Ther. 2009 Aug; 8(8):2286-95. | [2].Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1, 2-b]pyrazine-2, 3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6; 5(4):552-8.
MolecularWeight
266.64
Research Area
Cancer
Solubility
DMSO : 250 mg/mL (937.59 mM; ultrasonic and warming and heat to 60°C)
Target
Deubiquitinase; Apoptosis
Pathway
Cell Cycle/DNA Damage; Apoptosis

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

Amount: 50mg
Available: In stock
available

Delivery expected until 4/13/2023 

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