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HBX 41108

HBX 41108

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	50mg
Item no.	HY-101666-50mg
CASRN	924296-39-9
Available
Product Description	HBX 41108 is an uncompetitive inhibitor of ubiquitin-specific protease 7 (USP7) with an IC50 of 424 nM. HBX 41108 inhibits USP7-mediated p53 deubiquitination to stabilize p53 and inhibits cancer cell growth. HBX 41108 induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines.
StorageTemperature	4°C, sealed storage, away from moisture; In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Applications	Cancer-programmed cell death
Formula	C13H3ClN4O
References	[1].Colland F, et al. Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol Cancer Ther. 2009 Aug; 8(8):2286-95. \| [2].Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1, 2-b]pyrazine-2, 3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6; 5(4):552-8.
MolecularWeight	266.64
Research Area	Cancer
Solubility	DMSO : 250 mg/mL (937.59 mM; ultrasonic and warming and heat to 60°C)
Target	Deubiquitinase; Apoptosis
Pathway	Cell Cycle/DNA Damage; Apoptosis

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Amount: 50mg

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Delivery expected until 4/13/2023

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