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Wortmannin European Partner

Manufacturer MedChem Express
Category
Type Inhibitors
Specific against other
Amount 50mg
Item no. HY-10197-50mg
CASRN 19545-26-7
Available
Product Description
Wortmannin (SL-2052; KY-12420) is a potent, selective and irreversible PI3K inhibitor with an IC50 of 3 nM. Wortmannin also blocks autophagy formation, and potently inhibits Polo-like kinase 1 (PlK1) and Plk3 with IC50s of 5.8 and 48 nM, respectively.
StorageTemperature
Powder -20°C 3 years, 4°C 2 years; In solvent -80°C 6 months, -20°C 1 month
Applications
Cancer-Kinase/protease
Formula
C23H24O8
References
[1].Yano H, et al. Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. J Biol Chem. 1993 Dec 5; 268(34):25846-56. | [2].Moon EK, et al. Autophagy inhibitors as a potential antiamoebic treatment for Acanthamoeba keratitis. Antimicrob Agents Chemother. 2015 Jul; 59(7):4020-5. | [3].Liu Y, et al. Polo-like kinases inhibited by wortmannin. Labeling site and downstream effects. J Biol Chem. 2007 Jan 26; 282(4):2505-11. | [4].Wu Q, et al. Wortmannin inhibits K562 leukemic cells by regulating PI3k/Akt channel in vitro. J Huazhong Univ Sci Technolog Med Sci. 2009 Aug; 29(4):451-6. | [5].Lemke LE, et al. Wortmannin inhibits the growth of mammary tumors despite the existence of a novel wortmannin-insensitive phosphatidylinositol-3-kinase. Cancer Chemother Pharmacol. 1999; 44(6):491-7. | [6].Liu Y, et al. Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalianpolo-like kinase. Chem Biol. 2005 Jan; 12(1):99-107. | [7].Pobbati AV, et al. A combat with the YAP/TAZ-TEAD oncoproteins for cancer therapy. Theranostics. 2020 Feb 18; 10(8):3622-3635.
MolecularWeight
428.43
Research Area
Cancer
Solubility
DMSO : ≥ 50 mg/mL (116.71 mM)
Target
PI3K; Polo-like Kinase (PLK); Autophagy; Antibiotic
Isoform
PI3K; DNA-PK; PLK3; ATM; ATR; MLCK; Autophagy
Pathway
PI3K/Akt/mTOR; Cell Cycle/DNA Damage; Autophagy; Anti-infection

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

Amount: 50mg
Available: In stock
available

Delivery expected until 4/6/2023 

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