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Aderbasib

Aderbasib

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	50mg
Item no.	HY-10293-50mg
CASRN	791828-58-5
Available
Product Description	Aderbasib (INCB007839) is a potent, orally active and target specific low nanomolar hydroxamate-based inhibitor of ADAM10 and ADAM17. Aderbasib exhibits robust antineoplastic activity and can be used for cancer research, including diffuse large B-cell non-Hodgkin lymphoma, HER2+ breast cancer, gliomas, et al.
StorageTemperature	Powder -20°C 3 years, 4°C 2 years; In solvent -80°C 6 months, -20°C 1 month
Applications	Cancer-Kinase/protease
Formula	C21H28N4O5
References	[1].Lois Witters, et al. Synergistic inhibition with a dual epidermal growth factor receptor/HER-2/neu tyrosine kinase inhibitor and a disintegrin and metalloprotease inhibitor. Cancer Res. 2008 Sep 1; 68(17):7083-9. \| [2].Fei Yuan, et al. ADAM17 is an essential attachment factor for classical swine fever virus. PLoS Pathog. 2021 Mar 8; 17(3):e1009393.
MolecularWeight	416.47
Research Area	Cancer
Solubility	DMSO : 100 mg/mL (240.11 mM; Need ultrasonic)
Target	MMP
Isoform	ADAM10; ADAM17
Pathway	Metabolic Enzyme/Protease

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Amount: 50mg

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Delivery expected until 4/13/2023

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