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CMPD101

CMPD101

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	10mg
Item no.	HY-103045-10mg
CASRN	865608-11-3
Available
Product Description	CMPD101 is a potent, highly selective and membrane-permeable small-molecule inhibitor of GRK2/3 with IC50 of 18 nM and 5.4 nM, respectively. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKCα with IC50s of 3.1 μM , 2.3 μM, 1.4 μM and 8.1 μM, respectively. CMPD101 can be used for the study of heart failure.
StorageTemperature	Powder -20°C 3 years, 4°C 2 years; In solvent -80°C 6 months, -20°C 1 month
Applications	COVID-19-anti-virus
Formula	C24H21F3N6O
References	[1].Okawa T, et al. Design, Synthesis, and Evaluation of the Highly Selective and Potent G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure. J Med Chem. 2017 Aug 24; 60(16):6942-6990. \| [2].Yu Q, et al. Inhibition of prostatic smooth muscle contraction by the inhibitor of G protein-coupled receptor kinase 2/3, CMPD101.Eur J Pharmacol. 2018 Jul 15; 831:9-19.
MolecularWeight	466.46
Research Area	Cardiovascular Disease
Solubility	DMSO : 250 mg/mL (535.95 mM; Need ultrasonic)
Target	PKC; ROCK
Isoform	GRK2; GRK3; PKCα; ROCK2
Pathway	Epigenetics; TGF-beta/Smad; Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt

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Amount: 10mg

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Delivery expected until 4/13/2023

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