Comparison

PU02 European Partner

Manufacturer MedChem Express
Category
Type Inhibitors
Specific against other
Amount 100mg
Item no. HY-103118-100mg
CASRN 313984-77-9
Available
Product Description
PU02, a derivative of 6-MP (HY-13677), is a negative allosteric modulator (NAM) of 5-HT3 receptor, with IC50 values of 0.36 and 0.73 μM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively.
StorageTemperature
-20°C, stored under nitrogen; In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Applications
Cancer-programmed cell death
Formula
C16H12N4S
References
[1].Sarah M Trattnig, et al. Discovery of a novel allosteric modulator of 5-HT3 receptors: inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site. J Biol Chem. 2012 Jul 20; 287(30):25241-54. | [2].Xiao-Guang Yang, et al. 6-[(1-naphthylmethyl)sulfanyl]-9H-purine induces G2/M phase arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Eur J Pharmacol. 2012 Nov 15; 695(1-3):27-33.
MolecularWeight
292.36
Research Area
Cancer; Neurological Disease
Solubility
DMSO : 250 mg/mL (855.11 mM; Need ultrasonic)
Target
5-HT Receptor; Apoptosis
Isoform
5-HT3A Receptor; 5-HT 3 AB
Pathway
GPCR/G Protein; Neuronal Signaling; Apoptosis

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

Amount: 100mg
Available: In stock
available

Delivery expected until 4/13/2023 

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