PU02

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	100mg
Item no.	HY-103118-100mg
CASRN	313984-77-9
Available
Product Description	PU02, a derivative of 6-MP (HY-13677), is a negative allosteric modulator (NAM) of 5-HT3 receptor, with IC50 values of 0.36 and 0.73 μM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively.
StorageTemperature	-20°C, stored under nitrogen; In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Applications	Cancer-programmed cell death
Formula	C16H12N4S
References	[1].Sarah M Trattnig, et al. Discovery of a novel allosteric modulator of 5-HT3 receptors: inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site. J Biol Chem. 2012 Jul 20; 287(30):25241-54. \| [2].Xiao-Guang Yang, et al. 6-[(1-naphthylmethyl)sulfanyl]-9H-purine induces G2/M phase arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Eur J Pharmacol. 2012 Nov 15; 695(1-3):27-33.
MolecularWeight	292.36
Research Area	Cancer; Neurological Disease
Solubility	DMSO : 250 mg/mL (855.11 mM; Need ultrasonic)
Target	5-HT Receptor; Apoptosis
Isoform	5-HT3A Receptor; 5-HT 3 AB
Pathway	GPCR/G Protein; Neuronal Signaling; Apoptosis

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Amount: 100mg

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Delivery expected until 4/13/2023

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