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CRANAD-2

CRANAD-2

Item no.	HY-103242-5mg
Manufacturer	MedChem Express
CASRN	1193447-34-5
Amount	5 mg
Quantity options	100 mg 10 mg 1 ea 1 mg 25 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.0
Formula	C23H25BF2N2O2
Citations	[1]Ran C, et al. Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-beta deposits. J Am Chem Soc. 2009 Oct 28;131(42):15257-61. [2]Ran C, et al. Non-conjugated small molecule FRET for differentiating monomers from higher molecular weight amyloid beta species. PLoS One. 2011 Apr 29;6(4):e19362.
Smiles	CN(C)C(C=C1)=CC=C1/C=C/C2=O[B+3]([F-])([F-])O=C(/C=C/C3=CC=C(N(C)C)C=C3)[CH-]2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neurodegeneration
Manufacturer - Targets	Amyloid-β
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Product Description	CRANAD-2 is a near-infrared (NIR) Aβ plaque-specific fluorescent probe. CRANAD 2 penetrates the blood brain barrier and has a high affinity for Aβ aggregates with a Kd of 38 nM[1][2].
Manufacturer - Research Area	Neurological Disease
Solubility	DMSO : 2.08 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Neuronal Signaling
Clinical information	No Development Reported

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HY-103242-5mg-safety-datasheet.pdf