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trans-Ned 19

trans-Ned 19

Item no.	HY-103316-50mg
Manufacturer	MedChem Express
CASRN	1354235-96-3
Amount	50 mg
Quantity options	10 mM/1 mL 10 mg 1 mg 50 mg 5 mg
Category	Cardiovascular Research Ischemia & Reperfusion Injury Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.33
Citations	[1]Zharkich IL, et al. Suppression of Histamine-Induced Relaxation of Rat Aorta and Calcium Signaling in Endothelial Cells by Two-Pore Channel Blocker trans-NED19 and Hydrogen Peroxide. Izv Akad Nauk Ser Biol. 2016 Jul;(4):430-438.\|[2]Nawrocki M, et al. Trans-Ned 19-Mediated Antagonism of Nicotinic Acid Adenine Nucleotide-Mediated Calcium Signaling Regulates Th17 Cell Plasticity in Mice. Cells. 2021 Nov 5;10(11):3039.\|[3]Trufanov SK, et al. The Role of Two-Pore Channels in Norepinephrine-Induced [Ca2+]i Rise in Rat Aortic Smooth Muscle Cells and Aorta Contraction. Cells. 2019 Sep 25;8(10):1144. \|[4]Goretzko J, et al. Leukocyte adhesion is governed by endolysosomal two pore channel 2 (TPC2). bioRxiv, 2021: 2021.09. 28.462104.\|[5]Nawrocki M. Adenine dinucleotide Ca2+ mobilizing second messengers modulate CD4+ T-cells differentiation and effector function. Staats-und Universitätsbibliothek Hamburg Carl von Ossietzky, 2021.\|[6]Arndt L, et al. NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa. Mol Biol Cell. 2014 Mar;25(6):948-64.
Smiles	O=C([C@@H]1CC2=C([C@@H](C3=CC=C(OC)C(CN4CCN(C5=CC=CC=C5F)CC4)=C3)N1)NC6=C2C=CC=C6)O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1354235-96-3
Similar products	1354235-96-3
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Calcium Channel
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	514.59
Product Description	trans-Ned 19 is a NAADP antagonist and TPC blocker. trans-Ned 19 suppresses the calcium signal and the rat aorta relaxation in response to low histamine concentrations. trans-Ned 19 increases the spontaneous acrosome reaction rate, alleviates anti-CD3 mAb-induced intestinal inflammation, and improves kidney damage in mice with nephrotoxic serum nephritis[1][2][3][4][5][6].
Manufacturer - Research Area	Inflammation/Immunology; Cardiovascular Disease
Solubility	DMSO: 100 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Membrane Transporter/Ion Channel; Neuronal Signaling
Isoform	Calcium Channel
Clinical information	No Development Reported

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HY-103316-50mg-safety-datasheet.pdf