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Eprotirome

Eprotirome

Item no.	HY-10473-5mg
Manufacturer	MedChem Express
CASRN	355129-15-6
Amount	5 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.77
Citations	[1]Martagón AJ, et al. The amelioration of hepatic steatosis by thyroid hormone receptor agonists is insufficient to restore insulin sensitivity in ob/ob mice. PLoS One. 2015 Apr 7;10(4):e0122987.\|[2]Rosalba Senese, et al. Thyroid hormone metabolites and analogues. Endocrine. 2019 Oct;66(1):105-114.
Smiles	O=C(O)CC(NC1=CC(Br)=C(OC2=CC=C(O)C(C(C)C)=C2)C(Br)=C1)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	KB2115
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Metabolism-sugar/lipid metabolism
Manufacturer - Targets	Thyroid Hormone Receptor
Shipping Temperature	Blue Ice
Storage Conditions	-20°C, 3 years (Powder)
Molecular Weight	487.14
Product Description	Eprotirome (KB2115) is a liver-selective thyroid hormone receptor (TR) agonist. KB2115 has modestly higher affinity for TRβ than for TRα. Eprotirome reduces low-density lipoprotein (LDL) cholesterol concentrations. Eprotirome can be used for dyslipidemias and obesity research[1][2].
Manufacturer - Research Area	Endocrinology; Metabolic Disease
Solubility	DMSO: 125 mg/mL (ultrasonic)
Manufacturer - Pathway	Vitamin D Related/Nuclear Receptor
Clinical information	Phase 3

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HY-10473-5mg-safety-datasheet.pdf