Comparison

PHA-543613 European Partner

Manufacturer MedChem Express
Category
Type Inhibitors
Specific against other
Amount 10mg
Item no. HY-105670-10mg
CASRN 478149-53-0
Available
Product Description
PHA-543613 is a potent, orally active, brain-penetrant and selective α7 nAChR agonist with a Ki of 8.8 nM. PHA-543613 displays selectivity for α7-nAChR over α3β4, α1β1γδ, α4β2 and 5-HT3 receptors. PHA-543613 can be used for the cognitive deficits of Alzheimer's disease and schizophrenia research.
StorageTemperature
Powder -20°C 3 years, 4°C 2 years; In solvent -80°C 6 months, -20°C 1 month
Applications
Neuroscience-Neurodegeneration
Formula
C15H17N3O2
References
[1].Nóra Bruszt, et al. Potentiation of cognitive enhancer effects of Alzheimer's disease medication memantine by alpha7 nicotinic acetylcholine receptor agonist PHA-543613 in the Morris water maze task. Psychopharmacology (Berl). 2021 Nov; 238(11):3273-3281. | [2].Donn G Wishka, et al. Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2, 3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship. J Med Chem. 2006 Jul 13; 49(14):4425-36.
MolecularWeight
271.31
Research Area
Neurological Disease
Target
nAChR
Pathway
Membrane Transporter/Ion Channel; Neuronal Signaling

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

Amount: 10mg
Available: In stock
available

Delivery expected until 4/20/2023 

Compare

Add to wishlist

Request delivery time

Ask a technical question

Submit a bulk request

Questions about this Product?
 
Close