Comparison

GNE 5729 European Partner

Item no. HY-107409-10mg
Manufacturer MedChem Express
CASRN 2026635-66-3
Amount 10 mg
Quantity options 100 mg 10 mg 1 ea 25 mg 50 mg 5 mg
Category
Type Inhibitors
Specific against other
Purity 99.50
Formula C17H10Cl2F3N5O
Citations [1]Villemure E, et al. GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile. ACS Med Chem Lett. 2016 Oct 31;8(1):84-89.
Smiles ClC1=C([C@H]2[C@H](C#N)C2)N3C(C=C1)=NC(CN4N=C(C(F)(F)F)C=C4Cl)=CC3=O
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Shipping condition Room temperature
Available
Manufacturer - Type
Reference compound
Manufacturer - Applications
Neuroscience-Neurodegeneration
Manufacturer - Targets
iGluR
Shipping Temperature
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight
428.20
Product Description
GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively.
Manufacturer - Research Area
Neurological Disease
Solubility
DMSO : 100 mg/mL (ultrasonic)
Manufacturer - Pathway
Membrane Transporter/Ion Channel; Neuronal Signaling
Isoform
NMDA Receptor
Clinical information
No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 10 mg
Available: In stock
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