Comparison

(S)-(+)-Dimethindene maleate European Partner

Manufacturer MedChem Express
Category
Type Inhibitors
Specific against other
Amount 5mg
Item no. HY-107647-5mg
CASRN 136152-65-3
Available
Product Description
(S)-(+)-Dimethindene maleate, an enantiomer, is a potent M2-selective muscarinic receptor antagonist (pA2 = 7.86/7.74; pKi = 7.78). (S)-(+)-Dimethindene maleate shows lower affinities for the muscarinic M1 (pA2 = 6.83/6.36; pKi = 7.08), the M3 (pA2 = 6.92/6.96; pKi = 6.70) and the M4 receptors (pKi = 7.00), respectively. (S)-(+)-Dimethindene maleate also is a histamine H1 receptor antagonist (pA2 = 7.48).
StorageTemperature
4°C, sealed storage, away from moisture; In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Applications
COVID-19-immunoregulation
Formula
C24H28N2O4
References
[1].Pfaff O, et al. The (S)-(+)-enantiomer of dimethindene: a novel M2-selective muscarinic receptor antagonist. Eur J Pharmacol. 1995; 286(3):229-240. | [2].Yang Y, et al. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. Cell. 2017; 169(2):243-257.e25.
MolecularWeight
408.49
Research Area
Inflammation/Immunology
Target
mAChR; Histamine Receptor
Isoform
muscarinic M2 receptor; muscarinic M1 receptor; muscarinic M4 receptor; muscarinic M3 receptor; H1 Receptor
Pathway
GPCR/G Protein; Neuronal Signaling; Immunology/Inflammation

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

Amount: 5mg
Available: In stock
available

Delivery expected until 4/13/2023 

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