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(S)-(+)-Dimethindene maleate

(S)-(+)-Dimethindene maleate

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	5mg
Item no.	HY-107647-5mg
CASRN	136152-65-3
Available
Product Description	(S)-(+)-Dimethindene maleate, an enantiomer, is a potent M2-selective muscarinic receptor antagonist (pA2 = 7.86/7.74; pKi = 7.78). (S)-(+)-Dimethindene maleate shows lower affinities for the muscarinic M1 (pA2 = 6.83/6.36; pKi = 7.08), the M3 (pA2 = 6.92/6.96; pKi = 6.70) and the M4 receptors (pKi = 7.00), respectively. (S)-(+)-Dimethindene maleate also is a histamine H1 receptor antagonist (pA2 = 7.48).
StorageTemperature	4°C, sealed storage, away from moisture; In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Applications	COVID-19-immunoregulation
Formula	C24H28N2O4
References	[1].Pfaff O, et al. The (S)-(+)-enantiomer of dimethindene: a novel M2-selective muscarinic receptor antagonist. Eur J Pharmacol. 1995; 286(3):229-240. \| [2].Yang Y, et al. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. Cell. 2017; 169(2):243-257.e25.
MolecularWeight	408.49
Research Area	Inflammation/Immunology
Target	mAChR; Histamine Receptor
Isoform	muscarinic M2 receptor; muscarinic M1 receptor; muscarinic M4 receptor; muscarinic M3 receptor; H1 Receptor
Pathway	GPCR/G Protein; Neuronal Signaling; Immunology/Inflammation

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Amount: 5mg

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Delivery expected until 4/13/2023

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