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TCN 213

TCN 213

Item no.	HY-107712-25mg
Manufacturer	MedChem Express
CASRN	556803-08-8
Amount	25 mg
Quantity options	100 mg 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	99.16
Citations	[1]McKay, S et al. “Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist.” British journal of pharmacology vol. 166,3 (2012): 924-37.\|[2]Edman S, et al. TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner. Neuropharmacology. 2012 Sep;63(3):441-9.
Smiles	O=C(CSC1=NN=C(NCC2=CC=CC=C2)S1)NCC3CCCCC3
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neurodegeneration
Manufacturer - Targets	iGluR
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Molecular Weight	376.54
Product Description	TCN 213 is a selective, surmountable, glycine-dependentlly GluN1/GluN2A NMDAR antagonist with IC50s of 0.55, 3.5, 40 μM in the presence of 75, 750, 7500 nM glycine, respectively. TCN 213 can be used to monitor, pharmacologically, the switch in NMDAR expression in developing cortical neurones[1][2].
Manufacturer - Research Area	Neurological Disease
Solubility	DMSO: 250 mg/mL (ultrasonic)
Manufacturer - Pathway	Membrane Transporter/Ion Channel; Neuronal Signaling
Isoform	NMDA Receptor
Clinical information	No Development Reported

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HY-107712-25mg-safety-datasheet.pdf