DG-041

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	5mg
Item no.	HY-10835-5mg
CASRN	861238-35-9
Available
Product Description	DG-041 is a potent, high affinity and selective EP3 receptor antagonist with IC50s of 4.6 nM and 8.1 nM in the binding and FLIPR assay, respectively. DG-041 inhibits PGE2 facilitation of platelet aggregation. DG-041 crosses the blood-brain barrier.
StorageTemperature	Powder -20°C 3 years, 4°C 2 years; In solvent -80°C 6 months, -20°C 1 month
Applications	Neuroscience-Neuromodulation
Formula	C23H15Cl4FN2O3S2
References	[1].Singh J, et al. Antagonists of the EP3 receptor for prostaglandin E2 are novel antiplatelet agents that do not prolong bleeding. ACS Chem Biol. 2009 Feb 20; 4(2):115-26. \| [2].Hategan G, et al. Heterocyclic 1, 7-disubstituted indole sulfonamides are potent and selective human EP3 receptorantagonists. Bioorg Med Chem Lett. 2009 Dec 1; 19(23):6797-800.
MolecularWeight	592.32
Research Area	Cardiovascular Disease
Solubility	DMSO : 250 mg/mL (422.07 mM; Need ultrasonic)
Target	Prostaglandin Receptor
Isoform	EP3 receptor
Pathway	GPCR/G Protein

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Amount: 5mg

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Delivery expected until 4/20/2023

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